Internal Ribosome Entry Site (IRES), loop B of domain IV, NMR structures of two enteroviral sequence variants, refined with residual dipolar couplings and NOE distances

10 NMR structures AUCCCU bulge variant PDB 1R7W BMRB 6076

10 structures AUUCCU bulge variant PDB 1R7Z BMRB 6077

stereo AUCCCU sequence variant: stems: yellow bulge: cyan C10: light blue AUUCCU sequence variant: stems: orange bulge: magenta U10: dark blue

AUCCCU bulge variant stereo

AUUCCU bulge variant stereo

Du Z., Ulyanov N.B., Yu J., Andino R. & James T.L. NMR structures of loop B RNAs from the stem-Loop IV domain of the Enterovirus internal ribosome enrty site: A single C to U substitution drastically changes the shape and flexibility of RNA. Biochemistry 43, 5757-71 (2004).