Internal Ribosome Entry Site (IRES), loop B of domain IV, NMR structures of two enteroviral sequence variants, refined with residual dipolar couplings and NOE distances



AUCCCU 10 structures
10 NMR structures
AUCCCU bulge variant

PDB 1R7W
BMRB 6076
AUUCCU 10 structures

10 structures
AUUCCU bulge variant

PDB 1R7Z
BMRB 6077
AUCCCU & AUUCCU
AUCCCU & AUUCCU
stereo
AUCCCU sequence variant:
stems: yellow
bulge: cyan
C10: light blue

AUUCCU sequence variant:
stems: orange
bulge: magenta
U10: dark blue

AUCCCU
AUCCCU
AUCCCU bulge variant
stereo


AUUCCU

AUUCCU
AUUCCU bulge variant
stereo



Du Z., Ulyanov N.B., Yu J., Andino R. & James T.L. NMR structures of loop B RNAs from the stem-Loop IV domain of the Enterovirus internal ribosome enrty site: A single C to U substitution drastically changes the shape and flexibility of RNA. Biochemistry 43, 5757-71 (2004).