I am an associate adjunct professor in the NMR Laboratory at UCSF in the Department of Pharmaceutical Chemistry.Genentech Hall600 16th Street, Suite S-126E San Francisco CA 94143-2280 Phone 415-514-4117 Fax 415-502-8298 e-mail mujeeb@picasso.ucsf.edu
I arrived in San Francisco during cold summer of 1990 and immediately fell in love with the place. Then, as a post doctoral fellow in the laboratory of Tom James, I started to work on solving NMR structure of a DNA sequence from HIV-1. Over the years, I have been surfing through various interesting DNA, peptides, proteins and presently, DNA/RNA hybrids and RNA molecule(s). I have worked in the direction of solving macromolecular solution structures with better accuracy, resolution and with the dynamic interpretation of NMR data, yielding conformational ensembles. For structure determination, I make use of methods like CORMA, MARDIGRAS, molecular dynamics and distance geometry etc. The main focus of my research continues to be the structural biology of HIV-1 genomic RNA and regulatory proteins that bind to it.
I received my doctorate in molecular biophysics at University of Roorkee, Roorkee (India). During my Ph.D. days, I was in the Department of Biosciences and Biotechnology, at Roorkee, studying Drug-DNA interactions by NMR and computational methods.